Inside our research, we were being in the position to substantially escalate the dose of CX-5461 beyond that attained in the main-in-human review in sufferers with hematologic cancers. The RP2D of 475 mg/m2 on days one, eight, and 15 of the 4-7 days cycle, was based on phototoxicity, which happened Irrespective of stringent UV gentle avoidance pr